Is DHEA right for you?
You read about using DHEA for infertility somewhere on the internet, and you’re wondering whether this might help you. There are multiple natural and drug options to treat infertility mentioned on the internet. The key is to know whether the particular treatment being espoused is right and appropriate for you. You are unique and have a specific reason for having difficulty conceiving. What worked for your best friend, cousin, or sister-in-law will not necessarily be the best option for you; she has an entirely different genetic and hormonal makeup than you.
What is it?
DHEA is the abbreviation for the hormone Dehydroepiandrosterone. It is a weak androgen (male-type hormone) and a precursor to androstenedione, testosterone, and estrogen.
What does it do?
Dehydroepiandrosterone affects the lining of the blood vessels, reduces inflammation, improves insulin sensitivity, blood flow, cellular immunity, body composition, bone metabolism, sexual function, and physical strength, protects the nervous system, improves cognitive function, and enhances memory. Sounds fantastic, doesn’t it? As with any hormone, too little is a bad thing, and so is too much.
How does it impact fertility?
Because DHEA is a precursor to hormones that lead to estrogen, it is intimately involved in the development of eggs (ovulation). So you need a certain amount of it for healthy egg development. DHEA levels decline as we age. The other function of the androgens in egg development is to act as moderators. Rather than having an egg only influenced by estrogen and popping out too quickly before it fully matures, Dehydroepiandrosterone and testosterone put the brakes on (lightly) to slow the egg down and give it time to develop fully. However, too much DHEA (as is often the case in PCOS) can inhibit ovulation.
How do I know if DHEA would be helpful for me?
There is research showing that DHEA can help with ovulation, particularly in older women who are trying to conceive. The person DHEA will help is someone whose hormone is on the low side. How would you know this? Well, it starts with having a blood test done for DHEAs. Wouldn’t the fertility clinic have done this? NO. I would estimate that only about 1 out of 20 women who are working with a fertility clinic have had their Dehydroepiandrosterone level tested. Without this vital information, you can’t (nor can the fertility clinic) possibly know whether DHEA is right for you!
Why would my DHEAs be low?
DHEAs levels decline with age, so it may be an age thing. But 75-90% of your Dehydroepiandrosterone comes from your adrenal glands. What are they? Adrenal glands are your stress glands. They help you deal with stress, but most of our adrenal glands are overworked and underpaid. They require copious amounts of vitamin C, B5, B6, magnesium, potassium and zinc. These vitamins and minerals get depleted, your adrenals can’t work correctly, and they can’t support the ovaries in producing estrogen and, therefore, eggs.
Why would my DHEAs be high?
This occurs in PCOS and is associated with insulin resistance. Insulin resistance occurs when your body produces insulin, but cells don’t respond to it effectively. Insulin promotes excessive production of DHEA by the ovaries and adrenal glands. Too much will inhibit ovulation. In addition to infertility, too much Dehydroepiandrosterone also causes several unwanted symptoms like acne, hair loss, irregular periods and excessive body or facial hair growth.
What should I do?
Have your DHEAs blood level checked. It’s one of many hormones that are often NOT checked by your family doctor OR fertility clinic, but maintaining healthy levels is vital for fertility. In my patients, if it hasn’t been done, I always order it along with all of those other hormones that haven’t been checked, even at a fertility clinic.
References:
Traish AM, Kang HP, Saad F, Guay AT. Dehydroepiandrosterone (DHEA)–a precursor steroid or an active hormone in human physiology. J Sex Med. 2011 Nov;8(11):2960-82; quiz 2983. doi: 10.1111/j.1743-6109.2011.02523.x.
Malik N, Kriplani A, Agarwal N, Bhatla N, Kachhawa G, Yadav RK. Dehydroepiandrosterone as an adjunct to gonadotropins in infertile Indian women with premature ovarian aging: A pilot study. J Hum Reprod Sci. 2015 Jul-Sep;8(3):135-41. doi: 10.4103/0974-1208.165142.
Singh N, Zangmo R, Kumar S, Roy KK, Sharma JB, Malhotra N, Vanamail P. A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve. Gynecol Endocrinol. 2013 Nov;29(11):989-92. doi: 10.3109/09513590.2013.824957. Epub 2013 Sep 4.
By Dr. Pamela Frank, BSc(Hons), ND
