A retrospective analysis looking at the data on fresh IVF and ICSI cycles from 1996-2012 found that while the use of ICSI had doubled between that period, ICSI use was associated with small but statistically significant decreases in implantation, pregnancy, live birth, multiple birth, and low birth weight rates compared with conventional IVF. The use of intracytoplasmic sperm injection (ICSI) was not associated with improved reproductive outcome compared to conventional in vitro fertilization (IVF), researchers reported.
Source: Sheree L. Boulet, DrPH, MPH; Akanksha Mehta, MD; Dmitry M. Kissin, MD, MPH; Lee Warner, PhD; Jennifer F. Kawwass, MD; Denise J. Jamieson, MD, MPH Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection JAMA. 2015;313(3):255-263. doi:10.1001/jama.2014.17985.
It is my opinion that forcing a pregnancy is not a healthy thing. It’s better to improve the health of the respective parents and remove barriers to fertility such as hormone imbalance or inadequacies, oxidative stress and nutrient deficiencies.